2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0739AS
    Citicoline-d9 sodium 99.81%
    Citicoline-d9 (Cytidine diphosphate-choline-d9) sodium is the deuterium labeled Citicoline sodium (HY-B0739A). Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study.
    Citicoline-d9 sodium
  • HY-N0737AR
    Harmine (Standard) 442-51-3
    Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.
    Harmine (Standard)
  • HY-N7032S1
    Uridine 5′-diphosphoglucose-13C6 disodium 2483735-04-0 98.35%
    Uridine 5′-diphosphoglucose-13C6 (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].
    Uridine 5′-diphosphoglucose-13C6 disodium
  • HY-P10737A
    CGGK acetate
    CGGK acetate is a control peptide of CAQK peptide (HY-P10216).
    CGGK acetate
  • HY-RS16307
    mt-Nd4 Mouse Pre-designed siRNA Set A

    mt-Nd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for mt-Nd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    mt-Nd4 Mouse Pre-designed siRNA Set A
  • HY-RS17433
    Piezo1 Mouse Pre-designed siRNA Set A

    Piezo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Piezo1 Mouse Pre-designed siRNA Set A
  • HY-RS29445
    Ndufaf6 Mouse Pre-designed siRNA Set A
    NDUFAF6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for NDUFAF6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    NDUFAF6 siRNA-1: 5 nmol (HPLC)
    NDUFAF6 siRNA-2: 5 nmol (HPLC)
    NDUFAF6 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Ndufaf6 Mouse Pre-designed siRNA Set A
  • HY-RS29446
    ATP6V1A Monkey Pre-designed siRNA Set A
    ATP6V1A Monkey Pre-designed siRNA Set A contains three designed siRNAs for ATP6V1A gene (Monkey), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    ATP6V1A siRNA-1: 5 nmol (HPLC)
    ATP6V1A siRNA-2: 5 nmol (HPLC)
    ATP6V1A siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    ATP6V1A Monkey Pre-designed siRNA Set A
  • HY-W005394
    2-Phenylpropan-1-amine hydrochloride 20388-87-8 98.96%
    2-Phenylpropan-1-amine hydrochloride, a phenethylamine compound, is an agonist of the human trace amine-associated receptor 1 (TAAR1).
    2-Phenylpropan-1-amine hydrochloride
  • HY-W009681
    1-(2-Methoxyphenyl)piperazine hydrochloride 5464-78-8 99.79%
    1-(2-Methoxyphenyl)piperazine hydrochloride is a key agent intermediate of antipsychotics with high affinity to the serotonin receptors and 5-HT, which can be used to synthesize the intestinal worm-repellent agents Piperazine phosphate (HY-B0912C) and Piperazine citrate (HY-17599), as well as Fluphenazine (HY-119980), dihydrochloride, Rifampicin (HY-B0272).
    1-(2-Methoxyphenyl)piperazine hydrochloride
  • HY-W010383
    3-Diethylamino-1-propanol 622-93-5 ≥98.0%
    3-Diethylamino-1-propanol is an tertiary amine compound with anticonvulsant activity.
    3-Diethylamino-1-propanol
  • HY-W013113
    BTMPS 52829-07-9
    BTMPS is a nicotine receptor (nAChR) antagonist that can lessen the negative effects of morphine on rats.
    BTMPS
  • HY-W015788
    1-Phenylethane-1,2-diol 93-56-1
    1-Phenylethane-1,2-diol (Styrene Glycol) is a benzyl diol compound, which is the major metabolite of Styrene. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics.
    1-Phenylethane-1,2-diol
  • HY-W017933
    Octahydroisoindole 21850-12-4 99.09%
    Octahydroisoindole (Perhydroisoindole) is a substance P antagonist that can cross the blood-brain barrier and is useful for the study of movement disorders associated with central nervous system diseases.
    Octahydroisoindole
  • HY-W036121
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone 895152-66-6 99.97%
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144 Impurity 3) is a precursor in the synthesis of synthetic cannabinoids.
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
  • HY-W045132
    N-Desbutyl Bupivacaine 15883-20-2
    N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl Bupivacaine
  • HY-W048995
    D-6-Oxo-pipecolinic acid 72002-30-3 ≥98.0%
    D-6-Oxo-pipecolinic acid is the D-enantiomer of 6-Oxo-pipecolinic acid. 6-Oxo-pipecolinic acid is the biomarkers associated with pyridoxine-dependent epilepsy (PDE-ALDH7A1).
    D-6-Oxo-pipecolinic acid
  • HY-W053587
    Triazolopyridinone 6969-71-7 99.99%
    Triazolopyridinone (3-Hydroxytriazolo[4,3-a]pyridine) is an intermediate in the synthesis of the antidepressant Trazadone (HY-B0478A).
    Triazolopyridinone
  • HY-W087433
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate 28705-46-6 99.78%
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC50 of 45.52 μM.
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate
  • HY-W105700
    Ethylenediaminetetraacetic acid sodium hydrate 10378-23-1 ≥98.0%
    Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.
    Ethylenediaminetetraacetic acid sodium hydrate
Cat. No. Product Name / Synonyms Application Reactivity